IL12RB1 polyclonal antibody
产品名称: IL12RB1 polyclonal antibody
英文名称: IL12RB1 polyclonal antibody
产品编号: PAB18563
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Goat polyclonal antibody raised against synthetic peptide of IL12RB1.
- Immunogen:
- A synthetic peptide corresponding to amino acids at internal region of human IL12RB1.
- Sequence:
- C-HVSVKNHSLDSVS
- Host:
- Goat
- Theoretical MW (kDa):
- 100
- Reactivity:
- Human
- Specificity:
- This antibody is expected to recognize isoform 1 (NP_005526.1) only.
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 0.5 mg/mL
- Storage Buffer:
- In 0.5 mg/mL Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:8000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Entrez GeneID:
- 3594
- Protein Accession#:
- NP_005526.1
- Gene Name:
- IL12RB1
- Gene Alias:
- CD212,IL-12R-BETA1,IL12RB,MGC34454
- Gene Description:
- interleukin 12 receptor, beta 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
- Other Designations:
- IL-12 receptor beta component,interleukin-12 receptor beta-1 chain
- Related Disease
- Adenocarcinoma
- Anemia
- Arthritis, Rheumatoid
- Asthma
- Asthma
- Bronchial Hyperreactivity
- Bronchiolitis, Viral
- Carcinoma, Hepatocellular
- Carcinoma, Non-Small-Cell Lung
- Cardiovascular Diseases
- Celiac Disease
- Chorioamnionitis
- Crohn Disease
- Crohn's disease
- Dermatitis, Atopic
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Disease Progression
- Edema