HNMT polyclonal antibody
产品名称： HNMT polyclonal antibody
英文名称： HNMT polyclonal antibody
产品编号： PAB1874
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of HNMT.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human HNMT.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Human histamine N-methyltransferase gene: structural characterization and chromosomal location.
Aksoy S, Raftogianis R, Weinshilboum R.Biochem Biophys Res Commun. 1996 Feb 15;219(2):548-54.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of HNMT polyclonal antibody (Cat # PAB1874) in HeLa cell line lysates (35 ug/lane). HNMT (arrow) was detected using the purified polyclonal antibody.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with HNMT polyclonal antibody (Cat # PAB1874), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 3176
- Protein Accession#:
- NP_008826;P50135
- Gene Name:
- HNMT
- Gene Alias:
- HMT,HNMT-S1,HNMT-S2
- Gene Description:
- histamine N-methyltransferase
- Gene Ontology:
- Hyperlink
- Gene Summary:
- In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq
- Other Designations:
- -
- Gene Pathway
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