LINGO1 (N-term) Peptide
产品名称: LINGO1 (N-term) Peptide
英文名称: LINGO1 (N-term) Peptide
产品编号: P2468
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of LINGO1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human LINGO1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models.
Inoue H, Lin L, Lee X, Shao Z, Mendes S, Snodgrass-Belt P, Sweigard H, Engber T, Pepinsky B, Yang L, Beal MF, Mi S, Isacson O.Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14430-5. Epub 2007 Aug 28.
- 2.
- TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions.
Satoh J, Tabunoki H, Yamamura T, Arima K, Konno H.Neuropathol Appl Neurobiol. 2007 Feb;33(1):99-107.
- 3.
- The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition.
Mosyak L, Wood A, Dwyer B, Buddha M, Johnson M, Aulabaugh A, Zhong X, Presman E, Benard S, Kelleher K, Wilhelm J, Stahl ML, Kriz R, Gao Y, Cao Z, Ling HP, Pangalos MN, Walsh FS, Somers WS.J Biol Chem. 2006 Nov 24;281(47):36378-90. Epub 2006 Sep 27.
- Applications
- Western Blot (Transfected lysate)
- Western blot analysis of LINGO1 (arrow) using rabbit LINGO1 polyclonal antibody (Cat # PAB2857). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the LINGO1 gene (Lane 2) (Origene Technologies).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human brain tissue reacted with LINGO1 polyclonal antibody (Cat # PAB2857) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 84894
- Protein Accession#:
- NP_116197;Q96FE5
- Gene Name:
- LINGO1
- Gene Alias:
- FLJ14594,LERN1,LRRN6A,MGC17422,UNQ201
- Gene Description:
- leucine rich repeat and Ig domain containing 1
- Omim ID:
- 609791
- Gene Ontology:
- Hyperlink
- Other Designations:
- leucine rich repeat neuronal 6A,leucine-rich repeat neuronal 6A,leucine-rich repeat neuronal protein 1