NFKBIB monoclonal antibody (M04), clone 3B5
产品名称： NFKBIB monoclonal antibody (M04), clone 3B5
英文名称： NFKBIB monoclonal antibody (M04), clone 3B5
产品编号： H00004793-M04
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against a partial recombinant NFKBIB.
- Immunogen:
- NFKBIB (AAH15528, 56 a.a. ~ 145 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- Sequence:
- EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARA
- Host:
- Mouse
- Reactivity:
- Human
- Isotype:
- IgG2a Kappa
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (35.53 KDa) .
- MSDS:
Download
- Applications
- Western Blot (Cell lysate)
- NFKBIB monoclonal antibody (M04), clone 3B5 Western Blot analysis of NFKBIB expression in HL-60 ( Cat # L014V1 ).
- Protocol Download
- Western Blot (Recombinant protein)
- Protocol Download
- Sandwich ELISA (Recombinant protein)
- Detection limit for recombinant GST tagged NFKBIB is approximately 3ng/ml as a capture antibody.
- Protocol Download
- Entrez GeneID:
- 4793
- GeneBank Accession#:
- BC015528
- Protein Accession#:
- AAH15528
- Gene Name:
- NFKBIB
- Gene Alias:
- IKBB,TRIP9
- Gene Description:
- nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
- Omim ID:
- 604495
- Gene Ontology:
- Hyperlink
- Gene Summary:
- NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM
- Other Designations:
- -
- Interactome
- Related Disease
- Arthritis, Rheumatoid
- Atherosclerosis
- Calcinosis
- Cardiovascular Diseases
- Connective Tissue Diseases
- Coronary Artery Disease
- Diabetes Mellitus, Type 2
- Disease Susceptibility
- Edema
- Empyema, Pleural
- Fetal Diseases
- Genetic Predisposition to Disease
- Head and Neck Neoplasms
- HIV Infections
- Inflammation
- Lymphoma, Non-Hodgkin
- Musculoskeletal Diseases
- Neoplasm Recurrence, Local
- Neoplasms, Second Primary