LRP6 polyclonal antibody
产品名称： LRP6 polyclonal antibody
英文名称： LRP6 polyclonal antibody
产品编号： PAB4736
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of LRP6.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human LRP6.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor.
Liu G, Bafico A, Harris VK, Aaronson SA.Mol Cell Biol. 2003 Aug;23(16):5825-35.
- 2.
- LDL-receptor-related proteins in Wnt signal transduction.
Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP, He X.Nature. 2000 Sep 28;407(6803):530-5.
- 3.
- Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family.
Brown SD, Twells RC, Hey PJ, Cox RD, Levy ER, Soderman AR, Metzker ML, Caskey CT, Todd JA, Hess JF.Biochem Biophys Res Commun. 1998 Jul 30;248(3):879-88.
- Applications
- Western Blot (Transfected lysate)
- Western blot analysis of LRP6 (arrow) using rabbit LRP6 polyclonal antibody (Cat # PAB4736). 293 cell lysate (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the LRP6 gene (Lane 2) (Origene Technologies).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with LRP6 polyclonal antibody (Cat # PAB4736) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.
- Entrez GeneID:
- 4040
- Protein Accession#:
- NP_002327;O75581
- Gene Name:
- LRP6
- Gene Alias:
- ADCAD2,FLJ90062,FLJ90421
- Gene Description:
- low density lipoprotein receptor-related protein 6
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The LRP6 gene encodes a member of the low density lipoprotein receptor (LDLR) gene family, which consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDLR proteins are comprised of the same basic structural motifs: an extracellular domain that contains LDLR binding repeats and EGF repeats with associated spacer domains containing the YWTD motif; a single transmembrane-spanning domain; and a C-terminal cytoplasmic domain that generally contains at least 1 copy of the NPXY motif (Brown et al., 1998 [PubMed 9704021]). LRP6 and LRP5 (MIM 603506) function as coreceptors for WNT (MIM 164820) ligands and thus play a role in WNT signaling, which is important in a wide variety of biologic processes during pre- and postnatal life in invertebrates and vertebrates (Kokubu et al., 2004 [PubMed 15469977]).[supplied by OMIM
- Other Designations:
- low density lipoprotein-related protein 6
- Gene Pathway
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Cardiovascular Diseases
- Coloboma
- Coronary Artery Disease
- Diabetes Mellitus, Type 2
- Disease Progression
- Dyslipidemias
- Edema
- Femoral Neck Fractures
- Fractures, Bone
- Genetic Predisposition to Disease
- Hip Fractures
- Lactose Intolerance
- Lung Neoplasms
- Macular Degeneration
- Microphthalmos
- Osteoarthritis
- Osteoarthritis, Hip